Relevant publications

Primary Mitochondrial Diseases

Chinnery PF.
Mitochondrial Disorders Overview. 2000 Jun 8 [Updated 2014 Aug 14]. In: Adam MP, Ardinger HH, Pagon RA, et al., editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2018. Available from: https://www.ncbi.nlm.nih.gov/books/NBK1224/

Russell OM, Gorman GS, Lightowlers RN, Turnbull DM.
Mitochondrial Diseases: Hope for the Future. Cell. 2020 Apr 2;181(1):168-188. doi: 10.1016/j.cell.2020.02.051. Epub 2020 Mar 26. PMID: 32220313.

Gorman GS et al.
Prevalence of nuclear and mitochondrial DNA mutations related to adult mitochondrial disease. Ann Neurol. 2015;77(5):753-759. doi:10.1002/ana.24362 Epub 2015 Mar 28. PMID: 25652200; PMCID: PMC4737121.

McElroy GS et al.
NAD+ Regeneration Rescues Lifespan, but Not Ataxia, in a Mouse Model of Brain Mitochondrial Complex I Dysfunction. Cell Metab. 2020 Aug 4;32(2):301-308.e6. doi: 10.1016/j.cmet.2020.06.003. Epub 2020 Jun 22. PMID: 32574562; PMCID: PMC7415718.

Pirinen E et al.
Niacin Cures Systemic NAD+ Deficiency and Improves Muscle Performance in Adult-Onset Mitochondrial Myopathy. Cell Metab. 2020 Jun 2;31(6):1078-1090.e5. doi: 10.1016/j.cmet.2020.04.008. Epub 2020 May 7. Erratum in: Cell Metab. 2020 Jul 7;32(1):144. PMID: 32386566.

Titov DV, Cracan V, Goodman RP, Peng J, Grabarek Z, Mootha VK.
Complementation of mitochondrial electron transport chain by manipulation of the NAD+/NADH ratio. Science. 2016 Apr 8;352(6282):231-5. doi: 10.1126/science.aad4017. Epub 2016 Apr 7. PMID: 27124460; PMCID: PMC4850741.

Seo KS et al.
KL1333, a Novel NAD+ Modulator, Improves Energy Metabolism and Mitochondrial Dysfunction in MELAS Fibroblasts. Front Neurol. 2018 Jul 5;9:552. doi: 10.3389/fneur.2018.00552. eCollection 2018. PubMed PMID: 30026729; PubMed Central PMCID: PMC6041391

Ehinger JK et al.
Cell-permeable succinate prodrugs bypass mitochondrial complex I deficiencyNat Commun. 2016 Aug 9;7:12317. doi: 10.1038/ncomms12317. PubMed PMID: 27502960; PubMed Central PMCID: PMC4980488

Thorburn DR, Rahman J, Rahman S.
Mitochondrial DNA-Associated Leigh Syndrome and NARP. 2003 Oct 30 [Updated 2017 Sep 28]. In: Adam MP, Ardinger HH, Pagon RA, et al., editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2018. Available from: https://www.ncbi.nlm.nih.gov/books/NBK1173/

Traumatic Brain Injury

Kelsen J et al.
Copenhagen Head Injury Ciclosporin (CHIC) study: A phase IIa safety, pharmacokinetics and biomarker study of ciclosporin in severe head injury patients. J Neurotrauma. 2019 Jun 18. doi: 10.1089/neu.2018.6369. [Epub ahead of print] PMID: 31210099

Karlsson M et al.
Neuroprotective Effects of Cyclosporine in a Porcine Pre-Clinical Trial of Focal Traumatic Brain Injury. J Neurotrauma. 2018 Jul 24. doi: 10.1089/neu.2018.5706. [Epub ahead of print] PMID: 29929438

Maas AIR et al.
Traumatic brain injury: integrated approaches to improve prevention, clinical care, and research. Lancet Neurol. 2017 Dec;16(12):987-1048. doi: 10.1016/S1474-4422(17)30371-X. Epub 2017 Nov 6. Review. PubMed PMID: 29122524

Cyclophilin inhibitors

Simón Serrano S et al.
Evaluation of NV556, a Novel Cyclophilin Inhibitor, as a Potential Antifibrotic Compound for Liver Fibrosis. Cells. 2019 Nov 8;8(11). pii: E1409. doi: 10.3390/cells8111409. PMID: 31717385

Kuo J et al.
Cyclophilin Inhibitor NV556 Reduces Fibrosis and Hepatocellular Carcinoma Development in Mice With Non-Alcoholic Steatohepatitis. Front Pharmacol. 2019 Sep 26;10:1129. doi: 10.3389/fphar.2019.01129. eCollection 2019. PMID: 31611801