Primära mitokondriella sjukdomar
Åsander Frostner E, Simón Serrano S, Chamkha I, Donnelly E, Elmér E, Hansson MJ
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Prevalence of nuclear and mitochondrial DNA mutations related to adult mitochondrial disease. Ann Neurol. 2015;77(5):753-759. doi:10.1002/ana.24362 Epub 2015 Mar 28. PMID: 25652200; PMCID: PMC4737121.
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NAD+ Regeneration Rescues Lifespan, but Not Ataxia, in a Mouse Model of Brain Mitochondrial Complex I Dysfunction. Cell Metab. 2020 Aug 4;32(2):301-308.e6. doi: 10.1016/j.cmet.2020.06.003. Epub 2020 Jun 22. PMID: 32574562; PMCID: PMC7415718.
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Niacin Cures Systemic NAD+ Deficiency and Improves Muscle Performance in Adult-Onset Mitochondrial Myopathy. Cell Metab. 2020 Jun 2;31(6):1078-1090.e5. doi: 10.1016/j.cmet.2020.04.008. Epub 2020 May 7. Erratum in: Cell Metab. 2020 Jul 7;32(1):144. PMID: 32386566.
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Complementation of mitochondrial electron transport chain by manipulation of the NAD+/NADH ratio. Science. 2016 Apr 8;352(6282):231-5. doi: 10.1126/science.aad4017. Epub 2016 Apr 7. PMID: 27124460; PMCID: PMC4850741.
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KL1333, a Novel NAD+ Modulator, Improves Energy Metabolism and Mitochondrial Dysfunction in MELAS Fibroblasts. Front Neurol. 2018 Jul 5;9:552. doi: 10.3389/fneur.2018.00552. eCollection 2018. PubMed PMID: 30026729; PubMed Central PMCID: PMC6041391.
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Cell-permeable succinate prodrugs bypass mitochondrial complex I deficiency. Nat Commun. 2016 Aug 9;7:12317. doi: 10.1038/ncomms12317. PubMed PMID: 27502960; PubMed Central PMCID: PMC4980488.
Bakare AB, Rao RR, Iyer S.
Cell-Permeable Succinate Increases Mitochondrial Membrane Potential and Glycolysis in Leigh Syndrome Patient Fibroblasts. Cells. 2021 Aug 31;10(9):2255. doi: 10.3390/cells10092255. PMID: 34571904; PMCID: PMC8470843.
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Traumatisk hjärnskada
Hansson MJ, Elmér E.
Cyclosporine as Therapy for Traumatic Brain Injury. Neurotherapeutics. 2023 Aug 10. doi: 10.1007/s13311-023-01414-z. Epub ahead of print. PMID: 37561274.
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Neuroprotective Effects of Cyclosporine in a Porcine Pre-Clinical Trial of Focal Traumatic Brain Injury. J Neurotrauma. 2018 Jul 24. doi: 10.1089/neu.2018.5706. [Epub ahead of print] PMID: 29929438.
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Cyklofilinhämmare
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Synergistic Effects of Sanglifehrin-Based Cyclophilin Inhibitor NV651 with Cisplatin in Hepatocellular Carcinoma. Cancers (Basel). 2022 Sep 20;14(19):4553. doi: 10.3390/cancers14194553. PMID: 36230472; PMCID: PMC9559492.
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Novel Cyclophilin Inhibitor Decreases Cell Proliferation and Tumor Growth in Models of Hepatocellular Carcinoma. Cancers (Basel). 2021 Jun 18;13(12):3041. doi: 10.3390/cancers13123041. PMID: 34207224; PMCID: PMC8234462.
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Evaluation of NV556, a Novel Cyclophilin Inhibitor, as a Potential Antifibrotic Compound for Liver Fibrosis. Cells. 2019 Nov 8;8(11). pii: E1409. doi: 10.3390/cells8111409. PMID: 31717385.
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Cyclophilin Inhibitor NV556 Reduces Fibrosis and Hepatocellular Carcinoma Development in Mice With Non-Alcoholic Steatohepatitis. Front Pharmacol. 2019 Sep 26;10:1129. doi: 10.3389/fphar.2019.01129. eCollection 2019. PMID: 31611801.
Övrigt
Piel S et al.
Succinate prodrugs as treatment for acute metabolic crisis during fluoroacetate intoxication in the rat. Mol Cell Biochem. 2022 Oct 25. doi: 10.1007/s11010-022-04589-9. Epub ahead of print. PMID: 36282352.